How is VOC diagnosed?

Table of Contents

VOC testing can be performed in two main ways:

The use of an onsite PID meter (photo-ionizing detector) for real-time total VOC levels (tVOCs)
The use of sorbent tubes or air-capturing devices for lab analysis (usually GCMS) or summa canisters and regulators to target a wide variety of compounds by EPA method TO-15.

How do you test for VOC exposure?

A blood test can show the amount of VOCs in a person’s body. If the concentrations are high enough, VOCs may cause health problems such as lung irritation. Long- term exposure to low concentrations of VOCs may damage the liver or kidneys. This study was conducted along with ATSDR’s dioxin study in 2002.

Is there a blood test for VOCs?

Volatile organic compounds are measured in specially collected whole blood samples by headspace solid-phase microextraction (SPME)/gas chromatography/isotope dilution mass spectrometry using a similar method as described by Blount, et al.

Is urine a VOC?

VOCs are low molecular weight substances generated as final products of cellular metabolism and emitted through a variety of biological matrices, such as breath, blood, saliva and urine. Urine stands out for its non-invasive nature, availability in large volumes, and the high concentration of VOCs in the kidneys.

How long do VOCs stay in blood?

The authors found a return to “normal” VOC levels after 2-3 months. The research was based on “real life” studies in Germany, not chamber tests. Use the 2-3 month timeframe only as a guide, as my experience in the tight home with strong sources indicates it can take much longer.

What are urine volatiles?

Volatiles, Qualitative, Urine – This panel includes acetone, isopropanol, methanol and ethanol.

What is an organic compound found in urine?

The most important organic substances are urea, uric acid and creatinine. Urea is a product formed by the liver from ammonia and carbon dioxide. Ninety-five percent of the nitrogen content of urine is in the form of this substance. Uric acid is an end-product of the oxidation of purines in the body.

How do you calculate VOC content?

To find the VOC emissions from an overall coating, first find the Overall VOC Content* of the coating. The Overall VOC Content is the Overall Weight of VOC in the Coating divided by the Total Parts in the Coating. Overall Weight of VOC – For each component, multiply its VOC of Material by the Mix Ratio.

What are VOC levels?

Volatile organic compounds (VOCs) are emitted as gases from certain solids or liquids. VOCs include a variety of chemicals, some of which may have short- and long-term adverse health effects. Concentrations of many VOCs are consistently higher indoors (up to ten times higher) than outdoors.

What are the VOCs found in urine?

The VOCs that were found both in this study in Tables 1 and 2 and in breast cancer cell lines include: 3-heptanone, benzaldehyde, 2,4-di-tert-butylphenol and 2-pentanone. Other than the four VOCs found in both mouse urine and cell lines, there are many VOCs that share common structures and functionalities.

Can VOCs in urine detect breast cancer?

Even though there were not many VOCs that were detected as potential biomarkers for breast cancer in mouse urine that were also observed in breast cancer cell lines, it still gives confirmation that some of the VOCs present in urine that change significantly are due to changes in the tumor itself.

How do you analyze urine VOCs in BALB/c mice?

After 4T1.2 tumor cells were injected into BALB/c mice either in the mammary pad or into the iliac artery, urine was collected, VOCs from urine headspace were concentrated by solid phase microextraction and results were analyzed by gas chromatography-mass spectrometry quadrupole time-of-flight.

What is the best way to analyze VOC biomarkers?

First, GC–MS is still the gold standard method to analyze VOC biomarkers. However, it is not an easy technique to implement in the clinical setting because it is expensive and not portable. Thus, more studies need to be done concerning MS-based techniques that are less expensive and allow real-time monitoring, such as SIFT-MS.