What is a summary of DNA replication?
Replication is the process by which a double-stranded DNA molecule is copied to produce two identical DNA molecules. DNA replication is one of the most basic processes that occurs within a cell.
Where does DNA replication occur in eukaryotes?
Eukaryotic DNA replication requires multiple replication forks, while prokaryotic replication uses a single origin to rapidly replicate the entire genome. DNA replication always occurs in the nucleus.
What is the importance of DNA replication?
Cells must replicate their DNA before they can divide. This ensures that each daughter cell gets a copy of the genome, and therefore, successful inheritance of genetic traits. DNA replication is an essential process and the basic mechanism is conserved in all organisms.
Where does DNA replication occur in eukaryotic cells?
What is eukaryotic DNA replication?
Eukaryotic DNA Replication. The mechanism of eukaryotic DNA replication is similar to that of prokaryotic DNA replication. However, eukaryotic DNA replication requires special consideration due to differences in DNA sizes, unique linear DNA end structures called telomeres, and distinctive DNA packaging that involves complexes with histones.
What are the essential steps of replication in eukaryotes?
The essential steps of replication are the same as in prokaryotes. Starting replication is more complex in eukaryotes. At the origin of replication, a pre-replication complex is made with other initiator proteins. Other proteins are then recruited to start the replication process.
Why does the DNA have to be made accessible to replicate?
The DNA must be made accessible in order for DNA replication to proceed. The chromatin (the complex between DNA and proteins) may undergo some chemical modifications, so that the DNA may be able to slide off the histones or otherwise be accessible to the enzymes of the DNA replication machinery.
What happens when the replication fork reaches the end of chromosomes?
When the replication fork reaches the end of the linear chromosome, there is no place for a primer to be made for the DNA fragment to be copied at the end of the chromosome. These ends thus remain unpaired, and over time these ends may get progressively shorter as cells continue to divide.