AdministratorWhich are the SGLT2 inhibitors?
SGLT2 inhibitors are a class of prescription medicines that are FDA-approved for use with diet and exercise to lower blood sugar in adults with type 2 diabetes. Medicines in the SGLT2 inhibitor class include canagliflozin, dapagliflozin, and empagliflozin.
What does SGLT2 stand for?
Sodium-glucose transport protein 2 (SGLT2) inhibitors are a class of medications used to treat type 2 diabetes. They’re also known as gliflozins. SGLT2 inhibitors prevent the reabsorption of glucose from blood that’s filtered through your kidneys, therefore facilitating glucose excretion in the urine.
Which SGLT2 is best?
Current Selective SGLT2 Inhibitors Of the three FDA approved drugs, empagliflozin has the greatest selectivity for SGLT2 compared to SGLT1, while canagliflozin is the least selective (5).
What are the most common side effects of SGLT2 inhibitors?
The most common side effects of SGLT2 inhibitors include genital yeast infections, flu-like symptoms and a sudden urge to urinate. The U.S. Food and Drug Administration also warns of more rare but serious issues such as amputations, kidney injury and ketoacidosis.
Where is SGLT2 found in the body?
SGLT2 (also known as SLC5A2) mRNA is almost exclusively expressed in the kidney, while SGLT1 (SLC5A1) mRNA is found mainly in the small intestine and is only expressed to a small extent in the kidney [6, 17].
Who should not take SGLT2 inhibitors?
Who Shouldn’t Take an SGLT2 Inhibitor? The FDA hasn’t approved these medications to treat type 1 diabetes. They’re not recommended for anyone who has had diabetic ketoacidosis, a serious complication of diabetes. SGLT2 inhibitors also aren’t that helpful for someone who already has severe kidney disease.
What is the eGFR cut off for SGLT2?
In this study, high-risk CKD group eligible for SGLT2i was defined as an eGFR ≥ 45 mL/min/1.73 m2 and UACR ≥ 30 mg/g [2].