Which nociceptors are involved in rheumatoid arthritis?

Table of Contents

Nociceptors innervating the synovium and subchondral bone are responsible for arthritic pain. In contrast, stretch receptors, innervating the fibrous capsule are responsible for proprioception. In RA, chronic inflammation is thought to result in structural and functional changes in the peripheral innervation of joints.

Is rheumatoid arthritis nociceptive or neuropathic?

Conclusion. Although RA pain has usually been classified as nociceptive pain, the present study clarified that a significant number of patients might have NeP. The present findings suggest that high disease activity and being overweight are related to NeP in RA patients.

Can Rheumatoid arthritis cause allodynia?

Leffler et al found that RA patients with more than 5 years of symptoms showed generalized allodynia to pressure as well as increased sensitivity to light touch and hyperalgesia to innocuous cold.

Is rheumatoid arthritis nociceptive?

Rheumatoid arthritis has always been considered an inflammatory joint disease, causing inflammatory or nociceptive pain.

What are the different types of nociceptors?

Most visceral nociceptors (those located on organs inside the body) are silent nociceptors. Polymodal: Polymodal nociceptors respond to mechanical, thermal, and chemical stimuli. Mechano-thermal: Mechano-thermal nociceptors respond to both mechanical and thermal stimuli.

What are the two types of nociceptive pain?

Article Table of Contents. There are two types of nociceptive pain: Somatic, which originates in your arms, legs, face, muscles, tendons, and superficial areas of your body, and visceral, which originates from your internal organs (for example, a stomachache or pain from a kidney stone).

Does nociceptor activity lead to pain?

Nociceptors are generally electrically silent (12) and transmit all-or-none action potentials only when stimulated. However, nociceptor activity does not per se lead to the perception of pain.

Are a-fiber nociceptors heat sensitive?

A-fiber nociceptors are predominately heat- and or mechanosensitive (A-MH, A-H, A-M) (19, 27) (Table (Table2);2); however, sensitivity to noxious cold is also observed (27–29).