## How do you calculate AUC for carboplatin?

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Carboplatin Dose (mg) = Target area under the curve (AUC mg/mL/min) x (GFR* + 25) *GFR estimated by calculated creatinine clearance using Cockcroft-Gault Equation (see below).

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**What does carboplatin AUC mean?**

AUC is the “area under the curve” – a figure that reflects the concentration of drug in the body that doctors want to achieve; GFR is the glomerular filtration rate – the rate at which an individual patient’s kidneys work; A is the ratio of this glomerular filtration rate to how quickly the kidneys get rid of …

### What is AUC formula?

AUC becomes useful for knowing the average concentration over a time interval, AUC/t. Also, AUC is referenced when talking about elimination. The amount eliminated by the body (mass) = clearance (volume/time) * AUC (mass*time/volume).

### What is AUC in carboplatin dosing?

Area under the curve (AUC) is a term that frequently used in pharmacokinetics. It describes the variation of a drug’s concentration in the blood’s plasma as a function of time. In practice, the trapezoidal rule is used to estimate AUC, and the drug’s concentration is measured at certain discrete points in time.

**How do you calculate drug doses?**

A basic formula, solving for x, guides us in the setting up of an equation: D/H x Q = x, or Desired dose (amount) = ordered Dose amount/amount on Hand x Quantity….Dimensional Analysis Method

- The clinician has 2 mg/mL vials in the automated dispensing unit.
- How many milliliters are needed to arrive at an ordered dose?

#### What is a good value for AUC?

The area under the ROC curve (AUC) results were considered excellent for AUC values between 0.9-1, good for AUC values between 0.8-0.9, fair for AUC values between 0.7-0.8, poor for AUC values between 0.6-0.7 and failed for AUC values between 0.5-0.6.