How do you calculate AUC for carboplatin?

How do you calculate AUC for carboplatin?

Carboplatin Dose (mg) = Target area under the curve (AUC mg/mL/min) x (GFR* + 25) *GFR estimated by calculated creatinine clearance using Cockcroft-Gault Equation (see below).

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What does carboplatin AUC mean?

AUC is the “area under the curve” – a figure that reflects the concentration of drug in the body that doctors want to achieve; GFR is the glomerular filtration rate – the rate at which an individual patient’s kidneys work; A is the ratio of this glomerular filtration rate to how quickly the kidneys get rid of …

What is AUC formula?

AUC becomes useful for knowing the average concentration over a time interval, AUC/t. Also, AUC is referenced when talking about elimination. The amount eliminated by the body (mass) = clearance (volume/time) * AUC (mass*time/volume).

What is AUC in carboplatin dosing?

Area under the curve (AUC) is a term that frequently used in pharmacokinetics. It describes the variation of a drug’s concentration in the blood’s plasma as a function of time. In practice, the trapezoidal rule is used to estimate AUC, and the drug’s concentration is measured at certain discrete points in time.

How do you calculate drug doses?

A basic formula, solving for x, guides us in the setting up of an equation: D/H x Q = x, or Desired dose (amount) = ordered Dose amount/amount on Hand x Quantity….Dimensional Analysis Method

  1. The clinician has 2 mg/mL vials in the automated dispensing unit.
  2. How many milliliters are needed to arrive at an ordered dose?

What is a good value for AUC?

The area under the ROC curve (AUC) results were considered excellent for AUC values between 0.9-1, good for AUC values between 0.8-0.9, fair for AUC values between 0.7-0.8, poor for AUC values between 0.6-0.7 and failed for AUC values between 0.5-0.6.