What causes high aspartate aminotransferase?

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High levels of AST in the blood may be a sign of hepatitis, cirrhosis, mononucleosis, or other liver diseases. High AST levels may also be a sign of heart problems or pancreatitis. If your results are not in the normal range, it doesn’t always mean that you have a medical condition that needs treatment.

What enzyme converts oxaloacetate to aspartate?

GOT2
GOT2 and another enzyme, MDH, are essential for the functioning of the shuttle. GOT2 converts oxaloacetate into aspartate by transamination. This aspartate as well as alpha-ketoglutarate return into the cytosol, which is then converted back to oxaloacetate and glutamate, respectively.

Which group of enzymes will aspartate transaminase fall under?

AST and ALT are two transaminase enzymes, which catalyze the reversible transfer of an α-amino group from aspartate (AST) or alanine (ALT) to α-ketoglutarate to create oxaloacetate (AST) or pyruvate (ALT) and glutamate.

What is the function of aspartate aminotransferase?

Aspartate aminotransferase is a part of the malate-aspartate shuttle in the myocardium, is involved in gluconeogenesis in the liver and kidney, glyceroneogenesis in the adipose tissue, and synthesis of neurotransmitters and neuro-glial pathway in the brain.

What does serum glutamic oxaloacetic transaminase do?

Serum Glutamic Oxaloacetic Transaminase (SGOT) is an enzyme that is normally present in liver and heart cells. It is released into blood when the liver or heart is damaged. Blood levels of SGOT are elevated with liver damage or with an insult to the heart and some medications can also raise its levels.

What is alanine aminotransferase used for?

Alanine aminotransferase (ALT) is an enzyme found primarily in the liver and kidney. It was originally referred to as serum glutamic pyruvic transaminase (SGPT). Normally, a low level of ALT exists in the serum. ALT is increased with liver damage and is used to screen for and/or monitor liver disease.

How do transferases work?

A transferase is any one of a class of enzymes that catalyse the transfer of specific functional groups (e.g. a methyl or glycosyl group) from one molecule (called the donor) to another (called the acceptor).