What is ATG serum sickness?

What is ATG serum sickness?

Serum sickness is caused by a type III immune complex–mediated hypersensitivity reaction to heterologous rabbit or equine serum proteins. Nonhuman proteins present in antithymocyte globulin (ATG) stimulate the production of IgG, IgM, IgA, and IgE antibodies.

Is ATG an immunosuppressant?

ATG has been linked to acute elevations in serum enzyme elevations shortly following infusions, but has not been linked to cases of clinically apparent liver injury. ATG is a potent immunosuppressive agent and may result in reactivation of hepatitis B in susceptible patients.

Can ATG cure aplastic anemia?

Anti-Thymocyte Globulin (ATG) ATG is approved in the U.S. to treat acquired aplastic anemia and to reduce the chance of organ rejection after a kidney or other organ transplant. It may also be used to treat MDS or reduce rejection after a bone marrow transplant.

What is ATG immunology?

In immunology, an antigen (Ag) is a molecule or molecular structure or any foreign particulate matter or a pollen grain that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response.

How do you get serum sickness?

Serum sickness is caused by nonhuman proteins in certain medications and treatments that your body mistakes as being harmful, causing an immune reaction. One of the most common types of medication that causes serum sickness is antivenom. This is given to people who’ve been bitten by a venomous snake.

How do you treat serum sickness?

Treatment for serum sickness is aimed at reducing symptoms. Your doctor may prescribe antihistamines or analgesics (NSAIDs), along with topical medications to relieve itching or rash. In serious cases, your doctor may prescribe corticosteroids, such as prednisone. Normally, there is no need for hospitalization.

How much does ATG treatment cost?

Table 2

Arm Mean Dose (mg/kg/day) Cost/Month ($US)
EPAG 150 30,151
h-ATG 3,366 12,108
Cyclosporine 505 2,013
Cyclosporine (low-dose) 168 796

What is the success rate of ATG treatment?

Immunosuppressive therapy with antithymocyte globulin (ATG) and cyclosporine is the standard treatment for patients with severe aplastic anemia who do not have a human leukocyte antigen-matched related donor; it leads to a response rate of 60 to 70%.

Is serum sickness reversible?

Prevention. There is no known way to prevent the development of serum sickness. People who have had serum sickness or drug allergy should avoid future use of the antiserum or drug.