## What is creatinine clearance Cockcroft-Gault formula?

The Cockcroft-Gault formula for estimating creatinine clearance (CrCl) should be used routinely as a simple means to provide a reliable approximation of residual renal function in all patients with CKD. The formulas are as follows: CrCl (male) = ([140-age] × weight in kg)/(serum creatinine × 72)

## What is the difference between the MDRD method and the Cockcroft-Gault’s to calculate creatinine clearance?

The Cockcroft-Gault equation estimates clearance of creatinine (3), whereas the MDRD estimates GFR (2). At present, for subgroups of people who are old, underweight, or overweight, no clear-cut advice exists regarding which formula is best used for optimal estimation of kidney function.

**Is Cockcroft-Gault formula accurate?**

The Cockcroft and Gault formula was further shown to be a reliable estimate of GFR in twelve studies comparing the results of the estimate with methods giving true GFR values (inulin; 2 studies with 196 patients) or more accurate GFR values (10 studies with 1218 patients; 3 studies with 99m-Tc-DPTA; 4 studies with 51Cr …

**Is Cockroft Gault still used?**

The Cockcroft and Gault formula (CG) was developed in 1973 using data from 249 men with creatinine clearance (CCr) from approximately 30 to 130 mL/m2. It is not adjusted for body surface area. CG is no longer recommended for use because it has not been expressed using standardized creatinine values.

### What’s the difference between GFR and creatinine clearance?

Creatinine Clearance ( CrCl ) versus Glomerular Filtration Rate ( GFR ) Creatinine clearance ( CrCl ) is an estimate of Glomerular Filtration Rate ( GFR ); however, CrCl is slightly higher than true GFR because creatinine is secreted by the proximal tubule (in addition to being filtered by the glomerulus).

### What is normal range for Cockcroft-Gault?

The normal range of CrCl is 110 to 150mL/min in males and 100 to 130mL/min in females.

**Which is more accurate GFR or creatinine clearance?**

If a laboratory is using standardized methods, creatinine clearance measurements will consistently be 10 to 20 percent higher than GFR in patients with a normal GFR and progressively higher as the GFR falls.

**What is normal creatinine clearance?**

Clearance is often measured as milliliters per minute (mL/min) or milliliters per second (mL/s). Normal values are: Male: 97 to 137 mL/min (1.65 to 2.33 mL/s). Female: 88 to 128 mL/min (1.496 to 2.18 mL/s).

#### What is the formula for calculating creatinine clearance?

– Creatinine 1 mg/dL is the baseline for a given patient with normal GFR – Creatinine 2 mg/dL is 50% reduction in GFR – Creatinine 4 mg/dL is 70 to 85% reduction in GFR – Creatine 8 mg/dL is 90 to 95% reduction in GFR

#### How do you calculate the GFR using the Cockcroft Gault?

Actual body weight will significantly overestimate renal function

**How to calculate creatinine clearance MedCalc?**

Calculator

**How to calculate Cockcroft Gault?**

Cockcroft-Gault CrCl = [(140-age) x (Wt in kg) x (0.85 if female)] / (72 x Cr) Note: The original Cockroft-Gault Equation listed here provides an estimate of creatinine clearance, but this original formula is not adjusted for body surface area and may be less accurate in obese patients.The Cockroft-Gault Equation typically overestimates creatinine clearance by approximately 10 to 30%.