What metabolic pathway produces uric acid?
Uric acid (UA) is the end product of the metabolic pathway for purines, the main constituents of nucleotides. The pathway of UA generation is shown in Figure 1. Briefly, inosine monophosphate (IMP) is derived from de novo purine synthesis and from purine salvage.
Is uric acid produced by metabolism?
Uric acid is generated from metabolic conversion of either exogenous (dietary) or endogenous purines, primarily in the liver and intestine. The immediate precursor of uric acid is xanthine, which is metabolized to uric acid by either xanthine oxidase or by its isoform, xanthine dehydrogenase.
What is uric acid cycle?
The uric acid cycle is a cyclic adaptation of the process used for mammalian purine catabolism. Inosine monophosphate (IMP) is formed which reacts with pyrophosphate to form hypoxanthine and 5-phosphoribosylpyrophosphate (PRPP). This reaction is catalysed by hypoxanthine phosphoribosyltransferase (EC 2.4.
How purines are degraded to uric acid in humans?
Adenosine and guanosine (purines) are finally degraded to uric acid by purine degradation pathway. ❏ In humans, primates, birds and reptiles the final product of purine degradation is uric acid. ➔ Uric acid is excreted in the urine.
What is the end product of purine metabolism?
Uric acid is the end product of purine metabolism in humans.
How is uric acid synthesized in the body?
Uric acid is synthesized mainly in the liver, intestines and the vascular endothelium as the end product of an exogenous pool of purines, and endogenously from damaged, dying and dead cells, whereby nucleic acids, adenine and guanine, are degraded into uric acid.
How purine is metabolized by salvage pathway?
Purines are also obtained through salvage of preformed purine bases, and uptake of cellular degradation products. In the purine salvage, HPRT catalyzes conversion of hypoxanthine and guanine to IMP and GMP respectively and adenine phosphoribosyltransferase (APRT) catalyzes conversion of adenine to AMP.
What is involved in purine degradation pathway?
General Background This pathway depicts the degradation of purine nucleotides to purine nucleosides, purine bases, and URATE. Further degradation is shown in the pathway llink. Purine degradation plays an important role in nitrogen metabolism in most organisms.
What is end product of purine metabolism?