Why was retigabine discontinued?

Why was retigabine discontinued?

Safety issues. In 2013 GSK announced that there were safety issues around the drug as it could cause a blue discolouration of the skin and eye abnormalities. Doctors were urged to review patients prescribed the drug and to re-evaluate benefits versus risk.

What does retigabine do?

Otherwise known as ezogabine, retigabine is an anticonvulsant licensed for the treatment of partial epilepsy.

What is the mechanism of action of perampanel?

Perampanel has a novel mechanism of action. Perampanel (PER) is a first in class orally active, selective, non-competitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor agonist. AMPA receptors are postsynaptic ionotropic excitatory receptors with glutamate binding sites.

Is ezogabine still available?

The anticonvulsant known as Potiga (ezogabine) in the US and as Trobalt (retigabine) in Europe will be discontinued by the manufacturer at the end of June.

What is the origin of ezogabine?

Retigabine (INN) or ezogabine (USAN) is an anticonvulsant used as an adjunctive treatment for partial epilepsies in treatment-experienced adult patients. The drug was developed by Valeant Pharmaceuticals and GlaxoSmithKline.

Is retigabine still used?

The manufacturer has withdrawn retigabine from clinical use in 2017.

What is another name for Fycompa?

Perampanel (per AM pa nel) is the generic name (non-brand name) of a seizure medicine with the brand name Fycompa (fye COM puh). The name or look may be different in other countries. The dose (measured in milligrams, abbreviated “mg”) usually will be the same.

Can you overdose on perampanel?

Perampanel is a novel antiepileptic drug (an amino-3-hydroxy-5-methyl-4-isoxazlepropionic acid glutamate receptor antagonist) with a long half-life, which is used for the adjunctive treatment of epilepsy. The literature available identifies a potential for prolonged unconsciousness in overdose.

What is topiramate good for?

Topiramate is used alone or with other medications to treat certain types of seizures including primary generalized tonic-clonic seizures (formerly known as a grand mal seizure; seizure that involves the entire body) and partial onset seizures (seizures that involve only one part of the brain).

What does Topamax do to your brain?

Topamax is thought to decrease abnormal excitement in the brain. Among other actions, Topamax affects the activity of the neurotransmitter gamma-aminobutyrate (GABA).